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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21e071bc42c02bb14d2483a39f437d03e070c626c3475283b32af9e7f4a64818' 
  AND token = 'JRrzBWDyN/SydonG7AtA/g1i0nBENnGPtd+dEt2Wf2w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}