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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '156b7e53654785b0587b6a42f13a362e1ecce2025cdfee07fccb98857e20997b' 
  AND token = 'U1UEKIdAYODWeRBUhAAhPnullPOEhDiSo3HJaTf2ox8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}