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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '325346916ba03aa2318c6c8f45e0c6fe9b46c30df95b7cf4b9b4c7ee24acc327' 
  AND token = 'pO3ITNaib8yxh1kxSWJvErd8e4vhcAB8/XZbofxDg0U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}