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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ac4a4baa1f226f7bf790cbbdfc4a7f589ea7415c1dd1c69f2a27196d5524532' 
  AND token = 'w57Ex/evq0SYcpUXNF91uRc/lyRubf8fVzOK0+sbJSg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}