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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43a222acb70c6d35d99447f962a3450ebfe443037e981516a13c50bf154c2d2e' 
  AND token = 'Q4v1SMN5rFkkWI7Be17HCLYAenLkoemMrYgACW5j3K8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}