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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c44ea2249c921b97b9a934eef505c54144b3084b36111d2c1769a788d49d5d4a' 
  AND token = '+222dI0Nrm6Txo/fLCUA07BuPP0DzHKLSEs4Ls5/Lfc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}