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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78ced4fbec8bb751a18670eb48588a40a3e34183acb96345dd3d15d9e15ac885' 
  AND token = 'LjDYQzChOy//zxczH+gSMWPXQispUd7bnmIZoOS9xyQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}