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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7220b7d0d1ae90d29d75fc850131d9ef207c9cc63c7a68667405be0b343d6897' 
  AND token = '6Xb0VjLEZeBtxQntq5eNkis55rqzYXbx0xC1bA7fg0A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}