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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '26a506f3dd4cde3744a2f5be024e836327b6aa2da80b733dd66e092a4dbe5a57' 
  AND token = 'ldS7ewEimtlLr5tdsoA9MQXS4TGpDk+PVMwqdrrcc6Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}