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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25a3c1d6a429733aea31bd07cec577139c2b64a4da92f00903ea25d0f5926d5c' 
  AND token = 'Z2BhF0U5oqK5KiaZzpMS6IAF+XlkE8oJxJ3ru70W1xE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}