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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01a96ac0d21a261c6138feeb502887fee9d15f1a562a4c8c644d5b090743e341' 
  AND token = '4CNT9IMlHqQ+XOggSTt5mgoAh9zQEi73pK9Rx3qz8JY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}