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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2674f9cdb7983753d01654b4504138f33c85eabee7aaec4664e5847a189c5675' 
  AND token = 'dennM0zsprPch9pvFifCecOaTUgKrb1gMr2vlXm0FAE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}