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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8878307417c931a36d4e83ab542dda2f5a3be95339355e490857b8479b13b3fe' 
  AND token = 'vQSE9hEMqzOcIUNCyv2MhtT1Kuqd1UTZTiFrqT6fz4A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}