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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21271ea30fb188343004da50c98c280fba26b4f72ff945d0e87af2fdd88430ac' 
  AND token = '6N+3vJU2SnQdln+nw6s2kskINf/ET83lpwfuibu8FmY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}