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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6bfb46bb8a35e266a1c1f49b89a201ac55e3b7332e219ccee039bd2f888e8422' 
  AND token = 'aGQ8TUBWeRb0Wtnyzv7mE45xHQVR5kM4vIaGPQmGvQI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}