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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '67155a1fb5efcc0945678a2993ee64d3e5f5092d940e57f83de2fd9d11df16c1' 
  AND token = 'OLw3/rBrCPEB5A+L5w0e1IAiKiwMlKLiF8nZMiWB/yk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}