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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '425db25ec7e27a6e82bba015f9546711715ec0d97d78f995e01af0872c8dadb6' 
  AND token = 'iHpk+l1c1nws8iOON2+Nf3IRmQCEwz2pbpbxU9bHhyg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}