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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '543e13df7fe171fb67df9281b69c0f95c9841fe2c9017903b266d08e993ebf66' 
  AND token = 'ZvJSyRsZa8Pf5QMWBOIKgO0qZG3Sq1AambwgGM7JqHc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}