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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bb81a2d55550e7b9e33b5abd9fa128fd5ef5978381c684216085f60433889679' 
  AND token = 'RuA26ycaVusdY2IYUiRoBJt4qG5j4XGeUl91ct3E1Ko=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}