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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '51ef60f9c67ece8a05d6a4faf1e6a206b0b97c5c857fb23d303480dbfb1e426e' 
  AND token = 'PsalCKw0fUQE1BjaN6BQDXqUWj0q3H9MNaGHGdnl5yk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}