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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd1fd429bb0864205e2f0b292eea0e1424822b5a6c89610fad11dca33dabbf827' 
  AND token = 'GAcR73kkYHguoN2fckOBxUGPr+9WgIqh2bRNFCpvexc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}