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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45e13b1e1c5133b78e1808201b573552c675dda2d1fb506f48bbc675dbd2d8a9' 
  AND token = 'UJDH0DuZuT+GfgL1n7XUSYwISO5sPa6iDa6oAUaePNs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}