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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d41b0644878cf301c280420b64bf4fef253712daaad81bbcc39e9297380a1b3' 
  AND token = '+GyXF8S4kDySTR/2HJg8mvmk3a4XVgilKkmCGo4J89U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}