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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2fa5a56caa22c1a3146b3e193adce0a1e489ab5cb6169685d40f37d037750940' 
  AND token = 'HTRYJkM7M7YwSMPwSG3XsWYpeUAu4fSwYCb6JVh3dRs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}