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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65ae73e8a49e0075d96e2fecbf88e31b34ec28b2e6a6c0d1d5434d2d4a045117' 
  AND token = 'DonL0DaXcAp9PoTSvCq1YLngHmB6xrGwCRTG1JyNxPw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}