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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65f3a62e4a180964d6dec2a393f5893522efb1111190dcedc8c2e23c88864f98' 
  AND token = '5tZcuUTuHF5ZhEtrIMVgFBJCHnBX5kvw7CbxzrhUn5I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}