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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f8e40c376d605b4791ed3156eda550d74097bfb765baf04e11f4c3a4e1730843' 
  AND token = 'DPVYa9n+WsKJD/e16LCz0KfwKDQxTOYVHVQPq4wgko0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}