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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'eb5444aa7b589f171457c8d3d2c739b18719a18b1021f9b1e23df60831a1871e' 
  AND token = 'DdgGdN9xYQFYcpzPrs4f6zcWUW14tD7pRRdStqc6HCQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}