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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '646fea6006cf06c2eee5472f9f0c12a420b0f606af9e62671bca40e4cf1c09f4' 
  AND token = 'cU2F/lMv5D/YjC5KY4prCWeeJ1xKHkGcrAYazbQ+Gxs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}