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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0439bd1c21052b7a2bdd054324b15d1dc335a727cb76898ffc60a8e3bdc88816' 
  AND token = '4+pR51WCnXMgywFOqRj1bdJHLWwhPpkG8dFcfGRN8qQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}