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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a83ee4abdea40fd998ff89f6f37134e3cb4cbb1d1947e320700f4c15256df3d' 
  AND token = 'bHBIZR2d/VrXyz+eIxfxfpWyPVPtvhEdWWzZ5Ua9fmA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}