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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21a22029f9608c9be64ebf6a331df32ca85aced17a119d52bc561d8373c46a87' 
  AND token = 'rXrPMWQuup4cIo87i68jtJ+8dPWwIEdCXwAOT3Xx8mQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}