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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d7f7d45dcfa533c10ceac7d3769eaaf76acf7070285e22d662b1519974d6e22' 
  AND token = 'CIIANCP3d48HDcTagDORUbn93msYoLcnE/M/dDDD150=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00057

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}