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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4f1ff71d1186939f42ee1ff090c8b3d16266191f2fde392676883f958b016452' 
  AND token = 'LCnNhkh2oAYi36TiTsocAUK45BR9H8sEqYm7RW1YxqM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}