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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a580871e9fbd38212e76c9a8c8a86a3e85e77b4805519ff334134ae4706bb9c0' 
  AND token = 'hMQ6y+KRj5tqESVZ8KQvtPV37dEnrAlzSvInTX2S63A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}