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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '11b248f0a1d4de415b9b6283b852bc61bc78905f95ee730da945a5a33af50545' 
  AND token = 'Z3vXWxyl+RTjYpiQD49xReNhe+EobwSxlEU6aIXsb5Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}