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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a728e4979a33893de0b70f6c7c004c894650c44013155af7125409a781a047d' 
  AND token = 'ADAFcKOLnpoVhWZO//7rdYucehdzD+xzfI+rtT6qlfU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}