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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef3a674a27b5fbc7d3548c1b533adf9882453a12dfaad19d1110014cc3cdd7e2' 
  AND token = 'DJRCICT016YdyoJW/iFvNAQYS9z0IlFHzlpDHIub7Fg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}