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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '11d41ffbbaffc769f3a36fd398f74e00eb14f00e19283b709301a6a61fa2b1cd' 
  AND token = '271BCgefeLli3YNS2rzSN3huzBWy6alrWCypAjDqYhU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}