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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01f4b20b0d78d977212bc3399578e3b46264e1c944762cca497245a10d9bff89' 
  AND token = 'ZVMXl6xGBEgFxTaakVL0gN42nZAngi9hnMHk58eKoXk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}