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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '800bd816de9235fccc3bbb65d3b00884ba69367a38148d62c4cbf6d6f4a89b7b' 
  AND token = 'JWZlRnH1uyXSnLAF/HmIQ1e6DbTv+8bkslsmE9B5hVM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}