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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7de7819cb112149476e4a02e7b846506aed1dc7c1f340c355d04da4f96c3df52' 
  AND token = 'iFxVby86+8vuPPtwEg+BxmvoOU5rPJbtMw9CMuP9xBI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}