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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45f84f6f25b893be64c07a26c55c89394da3c12062d582a38061c1a3ff3d9f65' 
  AND token = 'IWC3xxDdw3cis0uxqYmtcQWL6culUgU8iMix+5RPv8Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}