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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45f578092a9f0a4897dba8aae54f9f3bafc1b73d35a0fff820137eb9faa1a836' 
  AND token = 'nofRKmizjX9O3nGz7Dg5KHLdF6/k15vuoiLUeh6+viI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}