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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8a8181a138b82fde82bcee8ec506b3b0f18923391d4151dd260126405ff6be07' 
  AND token = 'CTkQJqJJyC+jvrc6Dk6TDN1yGVU331zSdCKBrCvHShA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}