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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ae4cb726c2a7b2f640dabe3e3c61671dfa2fb5df2ea045ae079414c205226d94' 
  AND token = 'RBSWMrCWO2RQA+F2X2gWnPOPmmc3omQ5Ytt7djSPBRg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}