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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fd130fc3f54bcc2f999d33c181dda1177bda35dcdf4b88ec657422000454d2e2' 
  AND token = 'Zk5s8fFZIlfk+vPP7wL+GVFM4AlYwCN+19TdJ3YVgWM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}