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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21ee35f42b6cc355d6d9e8c1637baca54610c13ad06a6a2cf3d12025f67313a3' 
  AND token = 'DKL1Qql2cztQ/VZ1ePMS/l0ar/+INpJAd8yUJLM8s/0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}