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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78accb1e9a5cfa83db673fabad6e06e65a08cc48412f8f4b04a3be181c4df251' 
  AND token = 'uLg7cRLIPh1YS8u0o6yVZgn431SpYCJHT7wuCap45jc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}