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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50279300def9fe4dd9e218dbf399b6580fc1608aacc036bee3875ee527caf037' 
  AND token = 'icmAAmHXNcNA3DfX2GwoAuHUFy1Wjr9vC0B5MXqhxG4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}